About 240 million people worldwide have chronic hepatitis B virus with the highest rates of infection in Africa and Asia, according to World Health Organisation (WHO).

People with chronic hepatitis B infection, which spreads through blood and body fluids, attacking the liver and resulting in an estimated 650,000 deaths each year - most of them in low and middle income countries, are at increased risk of dying from cirrhosis and liver cancer, it said.

WHO has issued its first-ever guidance for the treatment of chronic hepatitis B ‘WHO guidelines for the prevention, care and treatment of persons living in chronic hepatitis B infection.’

It lays out a simplified approach to care for people living with the infection, particularly with limited resources.

Effective medicines exist that can prevent people developing these conditions so they live longer. But most people who need these medicines are unable to access them or can only obtain substandard treatment, said a statement.

One reason for this is the lack of clear evidence-based guidance for countries (especially low- and middle-income countries) as to who should be treated and what medicines to use, it said.

Dr Stefan Wiktor, who leads WHO’s Global Hepatitis Programme, said: “Deciding who needs treatment for hepatitis B depends on a number of factors. These new guidelines, which give treatment recommendations that rely on simple, inexpensive tests, will help clinicians make the right decisions.”

The guidance covers the full spectrum of care from determining who needs treatment, to what medicines to use, and how to monitor people long-term.

The key recommendation include the use of a few simple non-invasive tests to assess the stage of liver disease to help identify who needs treatment; prioritising treatment for those with cirrhosis - the most advanced stage of liver disease; the use of two safe and highly effective medicines, tenofovir or entecavir, for the treatment of chronic hepatitis B; and regular monitoring using simple tests for early detection of liver cancer, to assess whether treatment is working, and if treatment can be stopped.

The special needs of specific populations, such as people co-infected with HIV, as well as children and adolescents, and pregnant women have also been considered.

The two recommended medicines are already available in many countries as generics, and thus are relatively inexpensive, costing as little as $5 per person per month.

“Because for so many people treatment is life-long it is important that patients can access these medicines at the lowest possible price” said Dr Wiktor.

A number of countries are beginning to develop hepatitis B treatment programmes, and the newly-released document also provide guidance on how to organise hepatitis care and treatment services.

The treatment can prolong life for people already infected with hepatitis B, but it is also important to focus on preventing new infections.

WHO has recommended that all children are vaccinated against hepatitis B, with a first dose given at birth. Some countries, particularly in Asia, have reduced the rates of childhood hepatitis B infection through universal childhood vaccination. The challenge now is to scale up efforts to ensure that all children worldwide are protected from the virus.

Another route of infection is through the reuse of medical equipment, in particular of syringes.

WHO has recently launched a new policy on injection safety that will also help prevent new hepatitis B infections. The policy calls for the worldwide use of ‘smart’ syringes to prevent the re-use of syringes or needles.

The new guidelines on treating hepatitis B follow on from the publication last year by WHO of its first ever guidelines on treating hepatitis C. - TradeArabia News Service