Roche's top drug rejected for breast cancer
London, July 6, 2012
Roche Holding's cancer drug Avastin has been rejected by Britain's healthcare cost agency as a first-line treatment for advanced breast cancer, the latest in a series of setbacks for this medicine.
The National Institute for Health and Clinical Excellence (NICE) said on Friday that although Avastin, when used in combination with the chemotherapy drug Xeloda, could delay cancer from progressing longer than chemotherapy alone, it did not appear to help breast cancer patients live longer overall.
There were also question marks over whether or not Avastin, known generically as bevacizumab, could improve a patient's quality of life, according to NICE's Ch ief Executive A ndrew Dillon.
"Taking these uncertainties into account as well as the high cost of the drug, the committee concluded that bevacizumab was not a cost-effective use of National Health Service resources," Dillon said in a statement.
Breast cancer is one of the most common cancers in Britain, with more than 48,000 women and around 300 men diagnosed with it each year.
Drug regulators in the US withdrew their approval o f Avastin for breast cancer l ast year, s aying the drug was not effective enough to justify its risks even if patients believe it has helped them live longer.
According to NICE's information, Avastin is available in 100-mg and 400-mg vials costing 242.66 pounds ($380)and 924.40 pounds ($1,400) ea ch, r espectively. For an average patient, the monthly cost of the drug would be around 3,689 pounds ($5,700).
Roche said it was unhappy about NICE's ruling.
"This is disappointing because Avastin in combination with capecitabine has proven to be an important treatment option for women who have a particularly aggressive form of breast ca ncer, whi ch has a poor prognosis," the Swiss drugmaker said in a statement.
NICE had been reviewing the use of Avastin with Xeloda as a first-line treatment of breast cancer that has spread in patients for whom treatment with other chemotherapy options is not considered appropriate. – Reuters
More Health & Environment Stories
- RAK Hospital launches urinary clinic for women
- NBAD backs Emiratis on Antarctica trip
- Cut sugar intake drastically urges WHO
- Al khaliji to fund Qatar recycling plant
- Qatar researcher in 360km breast cancer run
- New facilitator to open in DHCC
- Many countries lack capacity to prevent hearing loss
- QUIT NOW: Passive smoking hurts kids' arteries
- San Francisco to ban plastic water bottles
- GSK wins home toothpaste award for Sensodyne
- E-integration vital to GCC healthcare industry
- Fakih IVF unveils two new genetic tests
- 2 die from H1N1 in Oman
- Al Noor Hospitals targets domestic growth
- Medical panel on the way in Bahrain
- 40pc of UAE adults ‘have hypertension’
- Saudi diabetics urged to stay away from camels
- GCC readies plan to fight heart diseases
- Bahrain opens sickle cell hospital
- Hazardous waste focus for Oman summit
- Infectious viruses to be tracked by satellite in UAE
- Mafraq Hospital names new surgery chief
- Saudi health ministry seals BMJ partnership
- Need for medical simulation training highlighted
- UAE-France discuss healthcare collaboration
- Seha focus on patient centred services
- Saudi-Tokyo firms in wastewater technology JV
- Leading experts at Dubai diabetes conference
- UAE reliance on green energy on the rise
- DB unit backs therapeutic riding programme