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New seasonal flu vaccine to contain H1N1 strain

Geneva, February 18, 2010

The coming year's seasonal flu vaccine in the northern hemisphere should include protection against three strains of flu, including the pandemic H1N1 virus, the World Health Organisation recommended.

The composition of the vaccine, announced at the end of a closed-door four-day meeting of influenza experts that is closely followed by the world's vaccine makers, means governments that have stockpiled doses of H1N1 swine flu vaccine may now use them for part of the seasonal flu vaccine mix.

Some countries, including Germany, France and the United States, cut back their orders of the H1N1 swine flu jab after people were slow to take them up. The fact that people needed only one dose, and not two as originally thought, also contributed to oversupply.

"If they have the vaccine strain which is already made up and can be used, then they're ahead of the game," Keiji Fukuda, the WHO's top influenza expert, told Reuters after a public WHO session attended by representatives of pharmaceutical companies.   

The other strains are H3N2 -- which like H1N1 is a type of influenza A -- and influenza B.

Fukuda said national health regulatory authorities would have to decide whether to combine the three strains into a single "trivalent" shot, administer three separate vaccines, or use a separate H1N1 shot and combine the other two in one shot.

Flu vaccine makers such as GlaxoSmithKline and Sanofi-Aventis need the guidance to start formulating vaccines for the northern hemisphere's 2010/11 vaccine mix. The flu season usually begins in November.   

The decision was more complicated this year because of the pandemic, declared by the WHO last June. That raised the question of whether to replace the current H1N1 seasonal strain with the pandemic strain -- also known as California 7 -- which is now circulating more widely.

"Based on the analyses it is expected that A (H1N1) pandemic 2009, A (H3N2) and B viruses will co-circulate in the northern hemisphere 2010-2011 with the likelihood that the pandemic A (H1N1) 2009 viruses will predominate," the WHO said in a statement issued on Thursday.    

Seasonal H1N1 viruses were "unlikely to circulate at significant levels during the 2010-2011 northern hemisphere season; hence it has not been recommended for inclusion," it said.

The composition of the southern hemisphere's separate seasonal vaccine for 2010 was announced last September and also contains the H1N1 pandemic strain. - Reuters




Tags: WHO | Health | vaccine | flu | H1N1 |

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